Ever since seventh grade science class with good old Mrs. Malpede, DNA and genes have captured my full attention. The more recent application of gene replacement is an exciting new area of discovery that is being used in experimental trials to replace faulty genes with correctly fabricated ones, or to introduce new genes into a series. According to Science Daily, knockout genes, or genes that have been purposefully restrained from carrying out their duty, can be compensated by a newly introduced gene. This is astounding, and how is it possible? The new gene is incorporated into the DNA and readily replicated in natural cellular replication without it being regurgitated by the body. Are there any cases where the body does not accept the new gene? This does not seem plausible at first. However, the use of viral vectors, typically perceived as the lovely little flu that rips through elementary schools, can be manipulated and used as vessels to carry the proper gene and incorporate it into the geneome. This is similar to how HIV hides in the body's DNA and is unknowingly recreated by the body every time a cell divides. Is it possible to use splicing to create an entirely new genome? Not just enhancing previously existing genes? What properties have to be understood by the host and how do they affect the creation of a new gene? The first cells this method was tested on were white blood cells, how did it eventually reach the blueprint for life? Could this be used to cure diseases or genetic disorders that have already affted the body? If so, what would the risks be of this type or experiment?
http://www.genetherapynet.com/viral-vectors.html
http://www.news-medical.net/health/Gene-Therapy-History.aspx
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